Towards complex biomolecule analysis on chip
Microfluidic systems for medical and biological applications have rapidly evolved. The high surface to volume ratios associated with microfluidic devices is critical for their exploitation in many bioengineering applications, due to the rapid adsorption of biomolecules, especially proteins from the surrounding biological environment. Surface modification strategies capable of eliminating the non-specific adsorption of biomolecules are essential, if reliable and reproducible bioassays and analyses are to be operated. We provided a versatile method of creating ethylene glycol-based thin films in microfluidic channels using plasma polymerization to create a highly low-fouling surface. The potential applications of plasma polymers with various functional groups in protein separation and small molecule arrays to detect phospho-metabolites will also be discussed.
About the presenter
Malinda Salim received her BEng and PhD in Chemical Engineering from the University of Sheffield. Her doctoral research with Phillip Wright and Sally McArthur in applying advanced surface modification techniques to lab-on-chip applications was critical to her later postdoctoral research into on-surface detection in metabolomics with the ChELSI Institute, and lipid-based nanocarriers with Rauzah Hashim in University of Malaya. In 2016, Malinda joined Ben Boyd’s research group with Monash Institute of Pharmaceutical Sciences, focusing her research into oral drug formulations and developments, with a recent interest in understanding milk digestion and structure formation for paediatric formulations.
Time of presentation: 11am - 12pm